Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

Takeda G protein-coupled receptor 5 (TGR5) agonists induce systemic release of glucagon-like peptides (GLPs) from intestinal L cells, a potentially therapeutic action against metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD), and Type 2 diabetes...

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Bibliographic Details
Published in:Am J Physiol Gastrointest Liver Physiol
Main Authors: Finn, Patricia D., Rodriguez, David, Kohler, Jill, Jiang, Zhengfeng, Wan, Sindy, Blanco, Erick, King, Andrew J., Chen, Tao, Bell, Noah, Dragoli, Dean, Jacobs, Jeffrey W., Jain, Rakesh, Leadbetter, Michael, Siegel, Matthew, Carreras, Christopher W., Koo-McCoy, Samantha, Shaw, Karen, Le, Cathy, Vanegas, Sandra, Hsu, I-Hsin, Kozuka, Kenji, Okamoto, Keiko, Caldwell, Jeremy S., Lewis, Jason G.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459286/
https://ncbi.nlm.nih.gov/pubmed/30605011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00300.2018
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