RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

Ral GTPases are RAS effector molecules and by implication a potential therapeutic target for RAS mutant cancer. However, very little is known about their roles in stem cells and tissue homeostasis. Using Drosophila, we identified expression of RalA in intestinal stem cells (ISCs) and progenitor cell...

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Détails bibliographiques
Publié dans:Cell Stem Cell
Auteurs principaux: Johansson, Joel, Naszai, Mate, Hodder, Michael C., Pickering, Karen A., Miller, Bryan W., Ridgway, Rachel A., Yu, Yachuan, Peschard, Pascal, Brachmann, Saskia, Campbell, Andrew D., Cordero, Julia B., Sansom, Owen J.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459002/
https://ncbi.nlm.nih.gov/pubmed/30853556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.02.002
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