Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis

BACKGROUND: This study aimed to explore the molecular mechanism and clinical relevance of iguratimod in the regulation of human B cell terminal differentiation. METHODS: An in vitro human antibody-secreting cell (ASC) differentiation system was established to test the effect of iguratimod. B cell ph...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Ye, Yan, Liu, Mei, Tang, Longhai, Du, Fang, Liu, Yuanhua, Hao, Pei, Fu, Qiong, Guo, Qiang, Yan, Qingran, Zhang, Xiaoming, Bao, Chunde
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458835/
https://ncbi.nlm.nih.gov/pubmed/30971291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1874-2
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