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Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis
BACKGROUND: This study aimed to explore the molecular mechanism and clinical relevance of iguratimod in the regulation of human B cell terminal differentiation. METHODS: An in vitro human antibody-secreting cell (ASC) differentiation system was established to test the effect of iguratimod. B cell ph...
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| Veröffentlicht in: | Arthritis Res Ther |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6458835/ https://ncbi.nlm.nih.gov/pubmed/30971291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1874-2 |
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