Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes

Metformin was shown to sensitize multidrug resistant breast cancer cells; however, the mechanisms involved in this capacity need to be clarified. We investigated oxidative stress and inflammatory-related pathways during the induction of doxorubicin resistance in MCF-7 and MDA-MB-231 human breast can...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Marinello, Poliana Camila, Panis, Carolina, Silva, Thamara Nishida Xavier, Binato, Renata, Abdelhay, Eliana, Rodrigues, Juliana Alves, Mencalha, André Luiz, Lopes, Natália Medeiros Dias, Luiz, Rodrigo Cabral, Cecchini, Rubens, Cecchini, Alessandra Lourenço
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458149/
https://ncbi.nlm.nih.gov/pubmed/30971831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42357-w
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