Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes

Metformin was shown to sensitize multidrug resistant breast cancer cells; however, the mechanisms involved in this capacity need to be clarified. We investigated oxidative stress and inflammatory-related pathways during the induction of doxorubicin resistance in MCF-7 and MDA-MB-231 human breast can...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Marinello, Poliana Camila, Panis, Carolina, Silva, Thamara Nishida Xavier, Binato, Renata, Abdelhay, Eliana, Rodrigues, Juliana Alves, Mencalha, André Luiz, Lopes, Natália Medeiros Dias, Luiz, Rodrigo Cabral, Cecchini, Rubens, Cecchini, Alessandra Lourenço
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458149/
https://ncbi.nlm.nih.gov/pubmed/30971831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42357-w
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