Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits

Mycobacterium tuberculosis (Mtb) secretes proteases and peptidases to subjugate its host. Out of its sixty plus proteases, atleast three are reported to reach host macrophages. In this study, we show that Mtb also delivers a lysyl alanine aminopeptidase, PepN (Rv2467) into host macrophage cytosol. O...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Sharma, Nishant, Aggarwal, Suruchi, Kumar, Saravanan, Sharma, Rahul, Choudhury, Konika, Singh, Niti, Jayaswal, Praapti, Goel, Renu, Wajid, Saima, Yadav, Amit Kumar, Atmakuri, Krishnamohan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457555/
https://ncbi.nlm.nih.gov/pubmed/30969995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215123
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