Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits

Mycobacterium tuberculosis (Mtb) secretes proteases and peptidases to subjugate its host. Out of its sixty plus proteases, atleast three are reported to reach host macrophages. In this study, we show that Mtb also delivers a lysyl alanine aminopeptidase, PepN (Rv2467) into host macrophage cytosol. O...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sharma, Nishant, Aggarwal, Suruchi, Kumar, Saravanan, Sharma, Rahul, Choudhury, Konika, Singh, Niti, Jayaswal, Praapti, Goel, Renu, Wajid, Saima, Yadav, Amit Kumar, Atmakuri, Krishnamohan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457555/
https://ncbi.nlm.nih.gov/pubmed/30969995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215123
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