Complex Coacervation-Integrated Hybrid Nanoparticles Increasing Plasmid DNA Delivery Efficiency in vivo

Many polycation-based gene delivery vehicles have limited in vivo transfection efficiency because of their excessive exterior positive charges and/or PEGylation, both of which could result in premature dissociation and poor cellular uptake and trafficking. Here, we reported novel hybrid PEGylated na...

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Udgivet i:ACS Appl Mater Interfaces
Main Authors: Li, Yunfei, Humphries, Brock, Wang, Zhishan, Lang, Shuyao, Huang, Xuefei, Xiao, Hua, Jiang, Yiguo, Yang, Chengfeng
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457453/
https://ncbi.nlm.nih.gov/pubmed/27781434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsami.6b10306
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