Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway

PURPOSE: Reactive oxygen species (ROS)-induced cytotoxicity is an important mechanism by which cisplatin kills tumor cells. Glutathione peroxidase family (GPXs) is an important member of antioxidant system which metabolizes intracellular ROS and maintains homeostasis of cells. Altered expressions of...

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Veröffentlicht in:Biomed Res Int
Hauptverfasser: Chen, Baishen, Shen, Zhuojian, Wu, Duoguang, Xie, Xuan, Xu, Xia, Lv, Liangzhan, Dai, Honglue, Chen, Ju, Gan, Xiangfeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457285/
https://ncbi.nlm.nih.gov/pubmed/31032363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7640547
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