NUP98-HBO1–fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis

Chronic myelomonocytic leukemia (CMML) constitutes a hematopoietic stem cell (HSC) disorder characterized by prominent monocytosis and myelodysplasia. Although genome sequencing has revealed the CMML mutation profile, the mechanism of disease development remains unclear. Here we show that aberrant h...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood Adv
Päätekijät: Hayashi, Yoshihiro, Harada, Yuka, Kagiyama, Yuki, Nishikawa, Sayuri, Ding, Ye, Imagawa, Jun, Shingai, Naoki, Kato, Naoko, Kitaura, Jiro, Hokaiwado, Shintaro, Maemoto, Yuki, Ito, Akihiro, Matsui, Hirotaka, Kitabayashi, Issay, Iwama, Atsushi, Komatsu, Norio, Kitamura, Toshio, Harada, Hironori
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2019
Aiheet:
Myeloid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457235/
https://ncbi.nlm.nih.gov/pubmed/30944097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018025007
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