Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease

Patients with chronic graft-versus-host disease (cGVHD) have a paucity of regulatory CD4 T cells (CD4Tregs) that mediate peripheral tolerance. In clinical trials, daily low-dose interleukin-2 (IL-2) has been administered safely for prolonged periods in patients with steroid-refractory cGVHD. Periphe...

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Bibliografski detalji
Izdano u:Blood Adv
Glavni autori: Whangbo, Jennifer S., Kim, Haesook T., Nikiforow, Sarah, Koreth, John, Alho, Ana C., Falahee, Bryn, Kim, Soomin, Dusenbury, Katharine, Fields, Marie J., Reynolds, Carol G., Alyea, Edwin P., Armand, Philippe, Cutler, Corey S., Ho, Vincent T., Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2019
Teme:
Transplantation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457229/
https://ncbi.nlm.nih.gov/pubmed/30936059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018027474
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