Smad7 ameliorates TGFβ-mediated skin inflammation and associated wound healing defects but not the susceptibility to experimental skin carcinogenesis

We assessed roles of Smad7 in skin inflammation and wound healing using genetic and pharmacological approaches. In K5.TGFβ1/K5.Smad7 bigenic (double transgenic) mice, Smad7 transgene expression reversed TGFβ1 transgene-induced inflammation, fibrosis and subsequent epidermal hyperplasia, and molecula...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Invest Dermatol
Päätekijät: Li, Fulun, Bian, Li, Iriyama, Shunsuke, Jian, Zhe, Fan, Bin, Luo, Jing Jing, Wang, Dongyan D., Young, Christian D., Han, Gangwen, Wang, Xiao-Jing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457120/
https://ncbi.nlm.nih.gov/pubmed/30423327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.10.031
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