Smad7 ameliorates TGFβ-mediated skin inflammation and associated wound healing defects but not the susceptibility to experimental skin carcinogenesis

We assessed roles of Smad7 in skin inflammation and wound healing using genetic and pharmacological approaches. In K5.TGFβ1/K5.Smad7 bigenic (double transgenic) mice, Smad7 transgene expression reversed TGFβ1 transgene-induced inflammation, fibrosis and subsequent epidermal hyperplasia, and molecula...

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Vydáno v:J Invest Dermatol
Hlavní autoři: Li, Fulun, Bian, Li, Iriyama, Shunsuke, Jian, Zhe, Fan, Bin, Luo, Jing Jing, Wang, Dongyan D., Young, Christian D., Han, Gangwen, Wang, Xiao-Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457120/
https://ncbi.nlm.nih.gov/pubmed/30423327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.10.031
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