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Smad7 ameliorates TGFβ-mediated skin inflammation and associated wound healing defects but not the susceptibility to experimental skin carcinogenesis
We assessed roles of Smad7 in skin inflammation and wound healing using genetic and pharmacological approaches. In K5.TGFβ1/K5.Smad7 bigenic (double transgenic) mice, Smad7 transgene expression reversed TGFβ1 transgene-induced inflammation, fibrosis and subsequent epidermal hyperplasia, and molecula...
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| Publicado no: | J Invest Dermatol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6457120/ https://ncbi.nlm.nih.gov/pubmed/30423327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.10.031 |
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