Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model

BACKGROUND: Microglia play crucial roles in the maintenance of brain homeostasis. Activated microglia show a biphasic influence, promoting beneficial repair and causing harmful damage via M2 and M1 microglia, respectively. It is well-known that microglia are initially activated to the M2 state and s...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Koizumi, Takashi, Taguchi, Katsutoshi, Mizuta, Ikuko, Toba, Hiroe, Ohigashi, Makoto, Onishi, Okihiro, Ikoma, Kazuya, Miyata, Seiji, Nakata, Tetsuo, Tanaka, Masaki, Foulquier, Sébastien, Steinbusch, Harry W. M., Mizuno, Toshiki
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456949/
https://ncbi.nlm.nih.gov/pubmed/30971251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1467-7
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