Mouse skin passage of a Streptococcus pyogenes Tn917 mutant of sagA/pel restores virulence, beta-hemolysis and sagA/pel expression without altering the position or sequence of the transposon

BACKGROUND: Streptolysin S (SLS), the oxygen-stable hemolysin of Streptococcus pyogenes, has recently been shown to be encoded by the sagA/pel gene. Mutants lacking expression of this gene were less virulent in a dermonecrotic mouse infection model. Inactivation of the sagA/pel gene affect the expre...

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Hlavní autoři: Eberhard, Thomas H, Sledjeski, Darren D, Boyle, Michael DP
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2001
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC64569/
https://ncbi.nlm.nih.gov/pubmed/11801184
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