Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation

[Image: see text] In Nature, multicyclic peptides constitute a versatile molecule class with various biological functions. For their pharmaceutical exploitation, chemical methodologies that enable selective consecutive macrocyclizations are required. We disclose a combination of enzymatic macrocycli...

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Detaylı Bibliyografya
Yayımlandı:Org Lett
Asıl Yazarlar: Streefkerk, Dieuwertje E., Schmidt, Marcel, Ippel, Johannes H., Hackeng, Tilman M., Nuijens, Timo, Timmerman, Peter, van Maarseveen, Jan H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2019
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456872/
https://ncbi.nlm.nih.gov/pubmed/30912446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b00378
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