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Self-aggregation and coaggregation of p53 core fragment and its aggregation gatekeeper variant
Recent studies suggested that p53 aggregation can lead to loss-of-function (LoF), dominant-negative (DN) and gain-of-function (GoF) effects, with adverse cancer consequences. The p53 aggregation-nucleating (251)ILTIITL(257) fragment is a key segment in wild-type p53 aggregation; however, an I254R mu...
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| Pubblicato in: | Phys Chem Chem Phys |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6456058/ https://ncbi.nlm.nih.gov/pubmed/26923710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cp06538k |
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