Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: a potential role of BDNF up-regulation

BACKGROUND/PURPOSE: The main purpose of this study was to extend our previously reported showing potent neuroprotective effect of valproic acid (VPA) in primary midbrain neuro-glial cultures to investigate whether VPA could protect dopamine (DA) neurons in vivo against 6-hydroxydopamine (6-OHDA)-ind...

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Publicat a:J Formos Med Assoc
Autors principals: Lai, Ching-Long, Lu, Chun-Chung, Lin, Hui-Ching, Sung, Yueh-Feng, Wu, Yi Pin, Hong, Jau-Shyong, Peng, Giia-Sheun
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456053/
https://ncbi.nlm.nih.gov/pubmed/30031602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfma.2018.06.017
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