Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

Parkinson’s disease (PD) is characterized by the selective and progressive loss of dopaminergic (DA) neurons in the midbrain substantia nigra. Currently, available treatment is unable to alter PD progression. Previously, we demonstrated that valproic acid (VPA), a mood stabilizer, anticonvulsant and...

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Detalhes bibliográficos
Main Authors: Wu, Xuefei, Chen, Po See, Dallas, Shannon, Wilson, Belinda, Block, Michelle L., Wang, Chao-Chuan, Kinyamu, Harriet, Lu, Nick, Gao, Xi, Leng, Yan, Chuang, De-Maw, Zhang, Wanqin, Lu, Ru Band, Hong, Jau-Shyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579941/
https://ncbi.nlm.nih.gov/pubmed/18611290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145708009024
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