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O2.1. CIRCUIT MECHANISM MEDIATES THE EFFECTS OF SUB-CHRONIC KETAMINE ON STRIATAL DOPAMINE SYNTHESIS CAPACITY AND LOCOMOTOR ACTIVITY: A COMBINED CHEMOGENETICS/PET STUDY
BACKGROUND: Ketamine, an N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, induces psychotic-like effects in healthy human and exacerbates symptoms in patients with schizophrenia (Krystal et al., 1994, Lahti et al., 1991). Therefore, ketamine could be used to simulate the neurochemical alte...
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| Publicat a: | Schizophr Bull |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6455725/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbz021.185 |
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