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41.1 EARLY LIFE STRESS COMBINED WITH PREFRONTAL DISRUPTION OF STRESS REGULATION RENDERS NORMAL RATS SUSCEPTIBLE TO THE EMERGENCE OF A HYPERDOPAMINERGIC STATE IN ADULTS

BACKGROUND: Our prior work on the MAM model of schizophrenia showed that MAM-treated offspring are anxious (as defined in the elevated plus maze), hyper-responsive to stressors (footshock evoked vocalization) and have a hyperactive amygdala prepubertally, before the dopaminergic changes arise. Furth...

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Bibliografiset tiedot
Julkaisussa:Schizophr Bull
Päätekijät: Grace, Anthony, Gomes, Felipe, Zhu, Xiyu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6455518/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbz022.169
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