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S22. PRE-CLINICAL ASSESSMENT OF TAK-831, A SELECTIVE D-AMINO ACID OXIDASE INHIBITOR, IN ANIMAL MODELS OF SCHIZOPHRENIA
BACKGROUND: TAK-831 is a potent inhibitor of the DAAO enzyme being developed for the cognitive deficits and negative symptoms of schizophrenia. Inhibition of DAAO results in an increase in D-serine, a co-agonist of the NMDA receptor and a full agonist of the δ2 glutamate receptor. Augmentation of NM...
שמור ב:
| הוצא לאור ב: | Schizophr Bull |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6455322/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbz020.567 |
| תגים: |
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