A Chemoselective Strategy for Late Stage Functionalization of Complex Small Molecules with Polypeptides and Proteins

Conjugates between proteins and small molecules enable access to a vast chemical space that is not achievable with either type of molecule alone; however, the paucity of specific reactions capable of functionalizing proteins and natural products has presented a formidable challenge for preparing con...

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Veröffentlicht in:Nat Chem
Hauptverfasser: Cohen, Daniel T., Zhang, Chi, Fadzen, Colin M., Mijalis, Alexander J., Hie, Liana, Johnson, Kenneth D., Shriver, Zachary, Plante, Obadiah, Miller, Scott J., Buchwald, Stephen L., Pentelute, Bradley L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454892/
https://ncbi.nlm.nih.gov/pubmed/30397320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-018-0154-0
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