Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs

BACKGROUND: Deregulated ErbB signaling plays an important role in tumorigenesis of pancreatic cancer. However, patients with pancreatic cancer benefit little from current existed therapies targeting the ErbB signaling. Here, we explore the potential anti-tumor activity of Valproic acid against pancr...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Lin, Tingting, Ren, Qun, Zuo, Weimin, Jia, Ruxue, Xie, Linhui, Lin, Rong, Zhao, Hu, Chen, Jin, Lei, Yan, Wang, Ping, Dong, Huiyue, Huang, Lianghu, Cai, Jinquan, Peng, Yonghai, Yu, Zongyang, Tan, Jianming, Wang, Shuiliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454766/
https://ncbi.nlm.nih.gov/pubmed/30961642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1160-9
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