Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs

BACKGROUND: Deregulated ErbB signaling plays an important role in tumorigenesis of pancreatic cancer. However, patients with pancreatic cancer benefit little from current existed therapies targeting the ErbB signaling. Here, we explore the potential anti-tumor activity of Valproic acid against pancr...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Lin, Tingting, Ren, Qun, Zuo, Weimin, Jia, Ruxue, Xie, Linhui, Lin, Rong, Zhao, Hu, Chen, Jin, Lei, Yan, Wang, Ping, Dong, Huiyue, Huang, Lianghu, Cai, Jinquan, Peng, Yonghai, Yu, Zongyang, Tan, Jianming, Wang, Shuiliang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454766/
https://ncbi.nlm.nih.gov/pubmed/30961642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1160-9
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