The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins

Current evidence indicating a role of the human prion protein (PrP) in amyloid-beta (Aβ) formation or a synergistic effect between Aβ and prion pathology remains controversial. Conflicting results also concern the frequency of the association between the two protein misfolding disorders and the issu...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol Commun
Hoofdauteurs: Rossi, Marcello, Kai, Hideaki, Baiardi, Simone, Bartoletti-Stella, Anna, Carlà, Benedetta, Zenesini, Corrado, Capellari, Sabina, Kitamoto, Tetsuyuki, Parchi, Piero
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454607/
https://ncbi.nlm.nih.gov/pubmed/30961668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0706-6
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