Fear-Potentiated Startle Response as an Endophenotype:Evaluating Metrics and Methods for Genetic Applications

The modulation of the startle response (SR) by threatening stimuli (fear-potentiated startle; FPS), is a proposed endophenotype for disorders of the fearful-fearlessness spectrum. FPS has failed to show evidence of heritability, raising concerns. However, the metrics used to index FPS – and, importa...

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Publicado en:Psychophysiology
Autores principales: Savage, Jeanne E., Moore, Ashlee A., Sawyers, Chelsea K., Bourdon, Jessica L., Verhulst, Brad, Carney, Dever M., Moroney, Elizabeth, Machlin, Laura, Kaabi, Oumaima, Vrana, Scott, Grillon, Christian, Brotman, Melissa A., Leibenluft, Ellen, Pine, Daniel S., Roberson-Nay, Roxann, Hettema, John M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454577/
https://ncbi.nlm.nih.gov/pubmed/30613993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/psyp.13325
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