Fear-Potentiated Startle Response as an Endophenotype:Evaluating Metrics and Methods for Genetic Applications

The modulation of the startle response (SR) by threatening stimuli (fear-potentiated startle; FPS), is a proposed endophenotype for disorders of the fearful-fearlessness spectrum. FPS has failed to show evidence of heritability, raising concerns. However, the metrics used to index FPS – and, importa...

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Publicado en:Psychophysiology
Main Authors: Savage, Jeanne E., Moore, Ashlee A., Sawyers, Chelsea K., Bourdon, Jessica L., Verhulst, Brad, Carney, Dever M., Moroney, Elizabeth, Machlin, Laura, Kaabi, Oumaima, Vrana, Scott, Grillon, Christian, Brotman, Melissa A., Leibenluft, Ellen, Pine, Daniel S., Roberson-Nay, Roxann, Hettema, John M.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454577/
https://ncbi.nlm.nih.gov/pubmed/30613993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/psyp.13325
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