Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of this interface coupled with quantitative analysis of deletion mutants of H2A-H2B...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Padavannil, Abhilash, Sarkar, Prithwijit, Kim, Seung Joong, Cagatay, Tolga, Jiou, Jenny, Brautigam, Chad A, Tomchick, Diana R, Sali, Andrej, D'Arcy, Sheena, Chook, Yuh Min
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2019
Sujets:
Structural Biology and Molecular Biophysics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453568/
https://ncbi.nlm.nih.gov/pubmed/30855230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43630
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