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Development of a Protease Biosensor Based on a Dimerization-Dependent Red Fluorescent Protein

Dysregulated activity of the protease matriptase is a key contributor to aggressive tumor growth, cancer metastasis, and osteoarthritis. Methods for the detection and quantification of matriptase activity and inhibition would be useful tools. To address this need, we developed a matriptase-sensitive...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Mitchell, Aaron C., Alford, Spencer C., Hunter, Sean A., Kannan, Deepti, Sperberg, R. Andres Parra, Chang, Cheryl H., Cochran, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453536/
https://ncbi.nlm.nih.gov/pubmed/29125730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00715
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