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Development of a Protease Biosensor Based on a Dimerization-Dependent Red Fluorescent Protein

Dysregulated activity of the protease matriptase is a key contributor to aggressive tumor growth, cancer metastasis, and osteoarthritis. Methods for the detection and quantification of matriptase activity and inhibition would be useful tools. To address this need, we developed a matriptase-sensitive...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Mitchell, Aaron C., Alford, Spencer C., Hunter, Sean A., Kannan, Deepti, Sperberg, R. Andres Parra, Chang, Cheryl H., Cochran, Jennifer R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453536/
https://ncbi.nlm.nih.gov/pubmed/29125730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00715
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