The Stoichiometric Production of IL-2 and IFN-γ mRNA Defines Memory T Cells That Can Self-Renew After Adoptive Transfer in Humans

Adoptive immunotherapy using ex vivo–expanded tumor-reactive lymphocytes can mediate durable cancer regression in selected melanoma patients. Analyses of these trials have associated the in vivo engraftment ability of the transferred cells with their antitumor efficacy. Thus, there is intensive clin...

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Udgivet i:Sci Transl Med
Main Authors: Wang, Anran, Chandran, Smita, Shah, Syed A., Chiu, Yu, Paria, Biman C., Aghamolla, Tamara, Alvarez-Downing, Melissa M., Lee, Chyi-Chia Richard, Singh, Sanmeet, Li, Thomas, Dudley, Mark E., Restifo, Nicholas P., Rosenberg, Steven A., Kammula, Udai S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453124/
https://ncbi.nlm.nih.gov/pubmed/22932225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004306
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