Error-prone replication through UV lesions by DNA polymerase θ protects against skin cancers

Cancers from sun-exposed skin accumulate “driver” mutations, causally implicated in oncogenesis. Since errors incorporated during translesion synthesis (TLS) opposite UV lesions would generate these mutations, TLS mechanisms are presumed to underlie cancer development. To address the role of TLS in...

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Publicado en:Cell
Main Authors: Yoon, Jung-Hoon, McArthur, Mark J., Park, Jeseong, Basu, Debashree, Wakamiya, Maki, Prakash, Louise, Prakash, Satya
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453116/
https://ncbi.nlm.nih.gov/pubmed/30773314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.01.023
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