PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis

High-risk human papillomavirus (HPV) E7 proteins enable oncogenic transformation of HPV-infected cells by inactivating host cellular proteins. High-risk but not low-risk HPV E7 target PTPN14 for proteolytic degradation, suggesting that PTPN14 degradation may be related to their oncogenic activity. H...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hatterschide, Joshua, Bohidar, Amelia E., Grace, Miranda, Nulton, Tara J., Kim, Hee Won, Windle, Brad, Morgan, Iain M., Munger, Karl, White, Elizabeth A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452706/
https://ncbi.nlm.nih.gov/pubmed/30894485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819534116
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