PTEN arginine methylation by PRMT6 suppresses PI3K–AKT signaling and modulates pre-mRNA splicing

Arginine methylation is a ubiquitous posttranslational modification that regulates critical cellular processes including signal transduction and pre-mRNA splicing. Here, we report that the tumor-suppressor PTEN is methylated by protein arginine methyltransferase 6 (PRMT6). Mass-spectrometry analysis...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Feng, Jiawen, Dang, Yaping, Zhang, Weiqi, Zhao, Xuyang, Zhang, Cong, Hou, Zhiyuan, Jin, Yan, McNutt, Michael A., Marks, Andrew R., Yin, Yuxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452682/
https://ncbi.nlm.nih.gov/pubmed/30886105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811028116
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