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Defining a new nomenclature for the structures of active and inactive kinases
Targeting protein kinases is an important strategy for intervention in cancer. Inhibitors are directed at the active conformation or a variety of inactive conformations. While attempts have been made to classify these conformations, a structurally rigorous catalog of states has not been achieved. Th...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6452665/ https://ncbi.nlm.nih.gov/pubmed/30867294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814279116 |
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