Nebulised lipid–polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells

Modulation of microRNAs (miRNAs), endogenous regulators of gene expression, is a promising strategy for tackling inflammatory lung diseases. In this proof-of-concept study, we tested delivery of miR-17 to bronchial epithelial cells (BECs) using nebulised lipid–polymer hybrid nanoparticles (LPNs). Th...

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Bibliografiske detaljer
Udgivet i:ERJ Open Res
Main Authors: Vencken, Sebastian, Foged, Camilla, Ramsey, Joanne M., Sweeney, Louise, Cryan, Sally-Ann, MacLoughlin, Ronan J., Greene, Catherine M.
Format: Artigo
Sprog:Inglês
Udgivet: European Respiratory Society 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452044/
https://ncbi.nlm.nih.gov/pubmed/30972350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/23120541.00161-2018
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