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Mucosal and systemic SIV-specific cytotoxic CD4(+) T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques
A HIV vaccine that provides mucosal immunity is urgently needed. We evaluated an intranasal recombinant Fowlpox virus (rFPV) priming vaccine followed by intramuscular Modified Vaccinia Ankara (rMVA) booster vaccine, both expressing SIV antigens. The vaccination generated mucosal and systemic SIV-spe...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450945/ https://ncbi.nlm.nih.gov/pubmed/30952887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41506-5 |
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