Mucosal and systemic SIV-specific cytotoxic CD4(+) T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques

A HIV vaccine that provides mucosal immunity is urgently needed. We evaluated an intranasal recombinant Fowlpox virus (rFPV) priming vaccine followed by intramuscular Modified Vaccinia Ankara (rMVA) booster vaccine, both expressing SIV antigens. The vaccination generated mucosal and systemic SIV-spe...

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Publicado en:Sci Rep
Autores principales: Khanna, Mayank, Jackson, Ronald J., Alcantara, Sheilajen, Amarasena, Thakshila H., Li, Zheyi, Kelleher, Anthony D., Kent, Stephen J., Ranasinghe, Charani
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450945/
https://ncbi.nlm.nih.gov/pubmed/30952887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41506-5
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