Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle control in response to replication stress, making ATR inhibition a promising therapeutic strategy for cancer treatment. To identify genes whose loss makes...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Wang, Chao, Wang, Gang, Feng, Xu, Shepherd, Peter, Zhang, Jie, Tang, Mengfan, Chen, Zhen, Srivastava, Mrinal, McLaughlin, Megan E., Navone, Nora M., Hart, Glen Traver, Chen, Junjie
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450769/
https://ncbi.nlm.nih.gov/pubmed/30532030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0606-4
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