Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

OBJECTIVE: To identify shared polygenic risk and causal associations in amyotrophic lateral sclerosis (ALS). METHODS: Linkage disequilibrium score regression and Mendelian randomization were applied in a large‐scale, data‐driven manner to explore genetic correlations and causal relationships between...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Bandres‐Ciga, Sara, Noyce, Alastair J., Hemani, Gibran, Nicolas, Aude, Calvo, Andrea, Mora, Gabriele, Tienari, Pentti J., Stone, David J., Nalls, Mike A., Singleton, Andrew B., Chiò, Adriano, Traynor, Bryan J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450729/
https://ncbi.nlm.nih.gov/pubmed/30723964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25431
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