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T Cell Receptor Signals to NF-κB Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome
Antigen-mediated stimulation of the T cell receptor (TCR) triggers activation of nuclear factor κB (NF-κB), a key transcriptional regulator of T cell proliferation and effector cell differentiation. TCR signaling to NF-κB requires both the Carma1-Bcl10-Malt1 (CBM) complex and the inhibitor of κB (Iκ...
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| Veröffentlicht in: | Sci Signal |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450650/ https://ncbi.nlm.nih.gov/pubmed/24825920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004882 |
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