Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming

Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell (ESC)-like state by expression of single reprogramming factor. We used CRISPR activation to perform a genome-scale, reprogramming screen in EpiSCs and identified 142 candidate genes. Our screen validated a total...

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Publicado en:Stem Cell Reports
Autores principales: Yang, Jian, Rajan, Sandeep S., Friedrich, Mathias J., Lan, Guocheng, Zou, Xiangang, Ponstingl, Hannes, Garyfallos, Dimitrios A., Liu, Pentao, Bradley, Allan, Metzakopian, Emmanouil
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450436/
https://ncbi.nlm.nih.gov/pubmed/30905739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.02.010
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