Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming

Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell (ESC)-like state by expression of single reprogramming factor. We used CRISPR activation to perform a genome-scale, reprogramming screen in EpiSCs and identified 142 candidate genes. Our screen validated a total...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Yang, Jian, Rajan, Sandeep S., Friedrich, Mathias J., Lan, Guocheng, Zou, Xiangang, Ponstingl, Hannes, Garyfallos, Dimitrios A., Liu, Pentao, Bradley, Allan, Metzakopian, Emmanouil
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450436/
https://ncbi.nlm.nih.gov/pubmed/30905739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.02.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados