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The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis
D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D′D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. D′D3 forms...
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| Publicado no: | Blood |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450429/ https://ncbi.nlm.nih.gov/pubmed/30642920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-10-876300 |
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