Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry

Association with the D′D3 domain of von Willebrand factor (VWF) stabilizes factor VIII (FVIII) in the circulation and maintains it at a level sufficient to prevent spontaneous bleeding. We used negative-stain electron microscopy (EM) to visualize complexes of FVIII with dimeric and monomeric forms o...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Chiu, Po-Lin, Bou-Assaf, George M., Chhabra, Ekta Seth, Chambers, Melissa G., Peters, Robert T., Kulman, John D., Walz, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543227/
https://ncbi.nlm.nih.gov/pubmed/26065652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-641688
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