Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry

Association with the D′D3 domain of von Willebrand factor (VWF) stabilizes factor VIII (FVIII) in the circulation and maintains it at a level sufficient to prevent spontaneous bleeding. We used negative-stain electron microscopy (EM) to visualize complexes of FVIII with dimeric and monomeric forms o...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Chiu, Po-Lin, Bou-Assaf, George M., Chhabra, Ekta Seth, Chambers, Melissa G., Peters, Robert T., Kulman, John D., Walz, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2015
Assuntos:
Plenary Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543227/
https://ncbi.nlm.nih.gov/pubmed/26065652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-641688
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