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A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination
The Recombination Activating Genes, RAG1 and RAG2, are essential for V(D)J recombination and adaptive immunity. Mutations in these genes often cause immunodeficiency, the severity of which reflects the importance of the altered residue or residues during recombination. Here, we describe a novel RAG1...
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| Publicado no: | Blood |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450058/ https://ncbi.nlm.nih.gov/pubmed/30538136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-866939 |
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