Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs

Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-renewal, but how changes in metabolism affect gene expression is poorly understood. C-terminal binding proteins (CTBPs) are glycolytic sensors that through NADH binding link the metabolic state of the cell to its gene...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Arthur, Sophie A., Blaydes, Jeremy P., Houghton, Franchesca D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450050/
https://ncbi.nlm.nih.gov/pubmed/30880076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.02.005
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