Lower synaptic density is associated with depression severity and network alterations

Synaptic loss and deficits in functional connectivity are hypothesized to contribute to symptoms associated with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). The synaptic vesicle glycoprotein 2A (SV2A) can be used to index the number of nerve terminals, an indirect esti...

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Udgivet i:Nat Commun
Main Authors: Holmes, Sophie E., Scheinost, Dustin, Finnema, Sjoerd J., Naganawa, Mika, Davis, Margaret T., DellaGioia, Nicole, Nabulsi, Nabeel, Matuskey, David, Angarita, Gustavo A., Pietrzak, Robert H., Duman, Ronald S., Sanacora, Gerard, Krystal, John H., Carson, Richard E., Esterlis, Irina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449365/
https://ncbi.nlm.nih.gov/pubmed/30948709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09562-7
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