Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis.

Alcohol use in persons living with HIV (PLWH) worsens the severity of bacterial pneumonia. However, the exact mechanism(s) by which this occurs remain ill-defined. We hypothesized that alcohol in the setting of HIV infection decreases S. pneumoniae clearance from the lung through mechanisms mediated...

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Publicat a:Alcohol
Autors principals: Samuelson, Derrick R., Siggins, Robert W., Ruan, Sanbao, Amedee, Angela M., Sun, Jiusong, Zhu, Quan Karen, Marasco, Wayne A., Taylor, Christopher M., Luo, Meng, Welsh, David A., Shellito, Judd E.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449221/
https://ncbi.nlm.nih.gov/pubmed/30213614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alcohol.2018.08.012
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