A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes

AIMS/HYPOTHESIS: Identifying individuals suitable for monogenic autoimmunity testing and gene discovery studies is challenging: early-onset type 1 diabetes mellitus can cluster with additional autoimmune diseases due to shared polygenic risk and islet- and other organ-specific autoantibodies are pre...

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Publicat a:Diabetologia
Autors principals: Johnson, Matthew B., Patel, Kashyap A., De Franco, Elisa, Houghton, Jayne A. L., McDonald, Timothy J., Ellard, Sian, Flanagan, Sarah E., Hattersley, Andrew T.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448971/
https://ncbi.nlm.nih.gov/pubmed/29417186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4551-0
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