Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na(+)/H(+) exchanger, lowering of cytosolic Na(+) and vasodilation

AIMS/HYPOTHESIS: Sodium–glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) constitute a novel class of glucose-lowering (type 2) kidney-targeted agents. We recently reported that the SGLT2i empagliflozin (EMPA) reduced cardiac cytosolic Na(+) ([Na(+)](c)) and cytosolic Ca(2+) ([Ca(2+)](c)) concentr...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Uthman, Laween, Baartscheer, Antonius, Bleijlevens, Boris, Schumacher, Cees A., Fiolet, Jan W. T., Koeman, Anneke, Jancev, Milena, Hollmann, Markus W., Weber, Nina C., Coronel, Ruben, Zuurbier, Coert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448958/
https://ncbi.nlm.nih.gov/pubmed/29197997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4509-7
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