Full restoration of specific infectivity and strain properties from pure mammalian prion protein

The protein-only hypothesis predicts that infectious mammalian prions are composed solely of PrP(Sc), a misfolded conformer of the normal prion protein, PrP(C). However, protein-only PrP(Sc) preparations lack significant levels of prion infectivity, leading to the alternative hypothesis that cofacto...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Burke, Cassandra M., Walsh, Daniel J., Steele, Alexander D., Agrimi, Umberto, Di Bari, Michele Angelo, Watts, Joel C., Supattapone, Surachai
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448948/
https://ncbi.nlm.nih.gov/pubmed/30908557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007662
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